1107008-01-4Relevant academic research and scientific papers
Use of transesterified 1,3-diketoesters in the synthesis of trisubstituted pyrazoles and their biological screening
Siddiqui, Naqui-Jahan,Idrees, Mohammad,Khati, Niraj T.,Dhonde, Madhukar G.
, p. 85 - 94 (2013/08/24)
Starting from 2-acetylbenzofuran derivatives 1a-d, methyl/ethyl 4-substituted/unsubstituted benzofuran-2-yl)-2,4-dioxobutanoate 2a-d and 3a-d have been synthesized by Claisen's condensation reaction with diethyloxalate. The transesterified product, 1,3-diketoester 2a-d on condensation with phenyl hydrazine undergo cyclization to afford the corresponding methyl 5-(substituted/unsubstituted benzofuran-2-yl)-1-phenyl- 1H-pyrazole-3- carboxylate 4a-d, which upon further condensation with hydrazine hydrate yielded 5- (substituted/unsubstituted benzofuran-2-yl)-1-phenyl-1H-pyrazole-3- carbohydrazide 5a-d. The structures of the newly synthesized compounds 2a-d, 3a-d, 4a-d and 5a-d were characterized by their elemental analysis and spectral studies such as IR, 1H NMR, 13C NMR and MS. All the synthesized compounds were screened for their antimicrobial activity. Most of the synthesized compounds showed high sensitivity against the selected bacteria and fungi at various concentrations.
Synthesis and antimicrobial activities of some new pyrazoles oxadiazoles and isoxazole bearing benzofuran moiety
Siddiqui, Naqui-Jahan,Idrees, Mohammad,Khati,Dhonde
, p. 249 - 253 (2013/12/04)
ABSTRACT The synthesis of novel derivatives of pyrazole-3-carboxylate (3-5) from methyl 4-(benzofuran-2-yl)-24-dioxobutanoate (1) is reported. Synthesis of substituted 134-oxadiazoles (7-11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting from the 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3- carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR 1H NMR 13C NMR Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive Gramnegative bacteria and a fungus.
Synthesis and antimicrobial evaluation of some 1,3-thiazole, 1,3,4-thiadiazole, 1,2,4-triazole, and 1,2,4-triazolo[3,4-b][1,3,4]-thiadiazine derivatives including a 5-(benzofuran-2-yl)-1-phenylpyrazole moiety
Abdel-Wahab, Bakr F.,Abdel-Aziz, Hatem A.,Ahmed, Essam M.
scheme or table, p. 601 - 605 (2010/05/18)
Potassium hydrazinecarbodithioate were prepared by treatment of acid hydrazides with carbon disulfide in the presence of potassium hydroxide. Reaction of this potassium salt with hydrazine hydrate, phenacyl bromide, or hydrazonoyl chlorides afforded 1,2,4
Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives
Abdel-Wahab, Bakr F.,Abdel-Aziz, Hatem A.,Ahmed, Essam M.
experimental part, p. 734 - 739 (2009/04/06)
The reaction of ethyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate 2 with two moles of hydrazine hydrate afforded 5-(benzofuran-2-yl)-1H-pyrazole-3- carbohydrazide 4a, while its reaction with equimolar amount of phenylhydrazine gave ester 3b which then converte
