1107014-69-6

Basic information

• Product Name: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-Methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxaMide
• Synonyms: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-Methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxaMide
• CAS NO: 1107014-69-6
• Molecular Formula: C₂₅H₂₇N₅O₃
• Molecular Weight: 445.51358
• EINECS: -0
• Mol File: 1107014-69-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-Methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-Methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxaMide(1107014-69-6)
• EPA Substance Registry System: N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(4-(2-Methylbenzoyl)piperidin-1-yl)pyridazine-3-carboxaMide(1107014-69-6)

Safety Data

• Hazardous Substances Data: 1107014-69-6(Hazardous Substances Data)

Upstream product

• 1024604-99-6 6-chloropyridazine-3-carboxylic acid (2-hydroxy-2-pyridine-3-ylethyl)amide 
• 64671-34-7 piperidin-4-yl(o-tolyl)methanone hydrochloride 

Relevant articles and documents

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Starting from a known piperazine-based SCD-1 inhibitor, we obtained more potent benzoylpiperidine analogs. Optimization of the structure of the benzoylpiperidine-based SCD-1 inhibitors resulted in the identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-yl-ethyl)amide (24) which showed strong inhibitory activity against both human and murine SCD-1. In addition, this compound exhibited good oral bioavailability and demonstrated plasma triglyceride lowering effects in Zucker fatty rats in a dose-dependent manner after a 7-day oral administration (qd).