110703-08-7

Upstream product

• 2127-03-9 2,2'-dipyridyldisulphide 
• 110703-07-6 (2-Amino-thiazol-4-yl)-[(Z)-cyclohexylmethoxyimino]-acetic acid 
• 66338-99-6 ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate 
• 2550-36-9 Cyclohexylmethyl bromide 
• 103453-21-0 [(Z)-Cyclohexylmethoxyimino]-[2-(trityl-amino)-thiazol-4-yl]-acetic acid ethyl ester 
• 110703-06-5 ethyl (Z)-2-(2-aminothiazol-4-yl)-2-(cyclohexylmethoxyimino)acetate 

Downstream Products

• 110703-09-8 sodium 6β-<(Z)-2-(2-aminothiazol-4-yl)2-(cyclohexylmethoxyimino)acetamido>penicillanate 

Relevant academic research and scientific papers

&β-Lactamase-Stable Penicillins. Synthesis and Structure-Activity Relationships of (Z)-Alkyloxyimino Penicillins; Selection of BRL 44154

A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins has been prepared.New methodology has been developed to prepare tertiary alkyl oximes.High stability to β-lactamases and potent antibacterial activity have been achieved against Gram-positive and certain Gram-negative organisms.Activity against methicillin-resistant Staphylococcus aureus was an unexpected finding.The cyclopentyl analogue 4f, BRL 44154, has been selected for further study.