1107060-46-7Relevant academic research and scientific papers
Studies on the transformation of nitrosugars into branched chain iminosugars. Part II: Synthesis of (3R,4R,5R,6S)-2,2-bis(hydroxymethyl)azepane-3,4,5,6-tetraol
Otero, Jose M.,Estevez, Amalia M.,Soengas, Raquel G.,Estevez, Juan C.,Nash, Robert J.,Fleet, George W.J.,Estevez, Ramon J.
, p. 2443 - 2446 (2008)
The first stereocontrolled synthesis of (3R,4R,5R,6S)-2,2-bis-(hydroxymethyl)azepane-3,4,5,6-tetraol is described herein. The method involves a novel double Henry reaction of the 3,5-di-O-benzyl-6-deoxy-1,2-O-isopropylidene-6-nitro-α-d-glucofuranose with formaldehyde followed by a reductive ring closure to give the first branched 1,6-dideoxy-1,6-heptitol described.
