110721-38-5Relevant articles and documents
&β-Lactamase-Stable Penicillins. Synthesis and Structure-Activity Relationships of (Z)-Alkyloxyimino Penicillins; Selection of BRL 44154
Brown, Pamela,Calvert, Stephen H.,Chapman, Pauline C. A.,Cosham, Suzanne C.,Eglington, A. John,et al.
, p. 881 - 891 (2007/10/02)
A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins has been prepared.New methodology has been developed to prepare tertiary alkyl oximes.High stability to β-lactamases and potent antibacterial activity have been achieved against Gram-positive and certain Gram-negative organisms.Activity against methicillin-resistant Staphylococcus aureus was an unexpected finding.The cyclopentyl analogue 4f, BRL 44154, has been selected for further study.