110727-83-8

Upstream product

• 127420-02-4 (3R,5R,6S)-4-(Benzyloxycarbonyl)-5,6-diphenyl-3-(2'-furyl)-2,3,5,6-tetrahydro-1,4-oxazin-2-one 
• 98-01-1 furfural 

Downstream Products

• 588683-07-2 (S)-2-amino-2-(furan-2'yl)-ethanol 
• 127420-04-6 N-(Benzyloxycarbonyl)-D-α-2-furylglycine 
• 127358-24-1 D-α-2-Furylglycine methyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of arylglycines

The asymmetric synthesis of several arylglycines are reported. The methodology deployed involves either cuprate or Friedel - Crafts couplings to chiral bromoglycinates. The % ee's range from 82 to 94%. Both an oxidative and reductive protocol are employed to unmask the oxazinone chiral auxilliary providing the free α-amino acids.