110728-98-8

Basic information

• Product Name: 2-(4-Amino-phenyl)-propionyl chloride
• CAS NO: 110728-98-8
• Molecular Weight: 183.637
• Mol File: 110728-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-Amino-phenyl)-propionyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Amino-phenyl)-propionyl chloride(110728-98-8)
• EPA Substance Registry System: 2-(4-Amino-phenyl)-propionyl chloride(110728-98-8)

Safety Data

• Hazardous Substances Data: 110728-98-8(Hazardous Substances Data)

Upstream product

• 117551-07-2 (4-Amino-phenyl)-acetyl chloride 
• 1197-55-3 4-aminophenylacetic acid 
• 59430-62-5 2-(4-aminophenyl)propionic acid 

Relevant articles and documents

Presynaptic cholinergic modulators as potent cognition enhancers and analgesic drugs. 1. Tropic and 2-phenylpropionic acid esters

Previous studies have shown that (R)-(+)-hyoscyamine has analgesic activity as a consequence of increased ACh release following antagonism of central muscarinic autoreceptors. Since the enhancement of central cholinergic transmission could be beneficial for cognitive disorders, we manipulated (R)-(+)-hyoscyamine, synthesizing several derivatives of tropic and 2-phenylpropionic acids, with the aim of obtaining drugs which are able to increase ACh release and consequently to show analgesic and nootropic activities. The results showed that several new compounds are indeed potent analgesics (with an analgesic efficacy comparable to that of morphine) and that the most potent one ((±)-19, PG9) also has remarkable cognition- enhancing properties. Our study confirmed that the mechanism of action involves ACh release even if it is still unclear whether only muscarinic autoreceptors or, also, heteroreceptors are involved.