110744-50-8

Basic information

• Product Name: 2-(1-Hydroxy-1-methylethyl)-4-methoxyfuro<2,3-b>chinolin
• CAS NO: 110744-50-8
• Molecular Weight: 257.289
• Mol File: 110744-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-Hydroxy-1-methylethyl)-4-methoxyfuro<2,3-b>chinolin(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Hydroxy-1-methylethyl)-4-methoxyfuro<2,3-b>chinolin(110744-50-8)
• EPA Substance Registry System: 2-(1-Hydroxy-1-methylethyl)-4-methoxyfuro<2,3-b>chinolin(110744-50-8)

Safety Data

• Hazardous Substances Data: 110744-50-8(Hazardous Substances Data)

Upstream product

• 60623-06-5 trans-2,3-dihydro-3-hydroxy-4-methoxy-α,α-dimethylfuro[2,3-b]quinoline-2-methanol 

Relevant articles and documents

Synthesis of (+)-myrtopsine, (+)-7,8-dimethoxymyrtopsine, and related 2,3-dihydro-3-hydroxy-2-(1-hydroxy-1-methyl-ethyl)benzofuran natural products

The first syntheses of myrtopsine (8t) and 7,8-dimethoxymyrtopsine (9t) have been carried out by halogen-metal exchange of 3-iodo-4-methoxy-quinolin-2(1H)-ones (15) and (21) with i-PrMgCl followed by addition of 3,3-dimethyloxirane-2-carboxaldehyde (1). A two-step sequence leads selectively to trans-2,3-dihydro-3-hydroxy-2-(1-hydroxy-1-methylethyl)benzofurans (7t), (8t), (9t), (28), and (32) by conversion of a 2-iodophenol or a 3-iodo-4-methoxyquinolin-2(1H)-one to an aryl Grignard reagent and addition of 3-methyl-2-butenal, followed by threo selective epoxidation of the resulting allylic alcohol and cyclization with inversion.