110764-35-7

Basic information

• Product Name: (2S,3'Z)-Cefprozil
• Synonyms: (2S,3'Z)-Cefprozil;(6R,7R)-7-[(S)-2-Amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Cefprozil L-Epimer;Cefprozil L-Epimer (30 mg) ((6R,7R)-7-[(S)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(Z)-prop-1-enyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid);(2S,3a€Z)-Cefprozil
• CAS NO: 110764-35-7
• Molecular Formula: C₁₈H₁₉N₃O₅S
• Molecular Weight: 389.42556
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 110764-35-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 803.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.53±0.1 g/cm3(Predicted)
• PKA: 2.92±0.50(Predicted)
• CAS DataBase Reference: (2S,3'Z)-Cefprozil(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3'Z)-Cefprozil(110764-35-7)
• EPA Substance Registry System: (2S,3'Z)-Cefprozil(110764-35-7)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 110764-35-7(Hazardous Substances Data)

Usage

Uses

L-Epimer of Cefprozil (C243910), an semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture and is an antibacterial agent.

Upstream product

• 106447-44-3 cis-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid 
• 107937-01-9 trans-7-amino-3-propen-1-yl-3-cephem-4-carboxylic acid 
• 337307-47-8 potassium (D)-N-[1-methoxycarbonylpropen-2-yl]-α-amino-p-hydroxyphenylacetate 

Relevant articles and documents

Process for preparation of 7-[alpha-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid

A process for preparation of 7-[D-α-amino-α-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) igh purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.