1107646-68-3

Upstream product

• 7380-81-6 ethyl (dimethylsulfuranylidene)acetate 
• 70-11-1 α-bromoacetophenone 
• 1146142-22-4 Br^(1-)*C₆H₁₃O₃S⁽¹⁺⁾ 
• 15121-89-8 ethyl (E)-4-oxo-4-phenyl-2-butenoate 

Downstream Products

• 1107060-60-5 1-benzoylcyclopropane-2,3-dicarboxylic acid bis[(2-hydroxyethyl)amide] 

Relevant academic research and scientific papers

Design, synthesis and conformational analysis of turn inducer cyclopropane scaffolds: microwave assisted amidation of unactivated esters on catalytic solid support to obtain γ-turn mimic scaffolds

Novel constrained 1-aroyl-cyclopropane-2,3-cis-dicarboxylic acid bis-[(2-hydroxy-ethyl)-amides] (17a-e) with varied torsional angles have been synthesized in high yield from unactivated esters of 1-aroyl-2,3-cis-diethoxycarbonylcyclopropanes (15a-e) on a catalytic solid support with reduced reaction times by using the monomode-microwave irradiation; 15a-e were obtained by diastereoselective ethoxycarbonylmethylene transfer from a sulfur ylide to ethyl β-aroylacrylates (10a-e). Torsional angles and interatomic distance measurements on the energy minimized structures of the obtained molecules (17a-e, DFT, B3LYP/6-31G* level) have established these molecules as valuable γ-turn mimic scaffolds.