1107658-86-5

Upstream product

• 64-17-5 ethanol 
• 60-34-4 methylhydrazine 
• 93618-22-5 methyl 4-(3-bromophenyl)-2,4-dioxobutanoate 

Downstream Products

• 1107658-91-2 5-(3-benzofuran-2-yl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 1107658-92-3 5-(3-benzofuran-2-yl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 852816-28-5 5-(3-bromo-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid 
• 1107658-90-1 5-(3-benzofuran-2-yl-phenyl)-1-methyl-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

ISOXAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF

The present invention generally relates to an isoxazole derivative, a preparation therefor, and a use thereof. In particular, the present invention provides a farnesoid X receptor (FXR) agonist compound, and a stereoisomer, a tautomer, a polymorph, a solvate (e.g., a hydrate), a pharmaceutically acceptable salt, an ester, a metabolite, and an N-oxide, and the chemically protected forms and prodrugs thereof. The present invention further provides a preparation method for the compound, an intermediate thereof, and a pharmaceutical composition and kit containing the same and used thereof for treating FXR-mediated diseases or conditions.

PYRAZOL DERIVATIVES

The invention is concerned with novel pyrazol derivatives of formula (I), wherein R1, R2, R3, R4, X and Y are as defined herein, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor and/or CCR-5 receptor and can be used as medicaments.