1107662-18-9

Upstream product

• 22091-36-7 4-chloromethyl-2-(4-chlorophenyl)oxazole 
• 1107663-17-1 2-Amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}phenyl)pyridine-3,5-dicarbonitrile 
• 948017-13-8 4-{[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}benzaldehyde 
• 619-56-7 4-chlorobenzamide 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 1229002-55-4 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{6-[(tert-butoxycarbonyl)amino]hexanoate} 
• 1229002-53-2 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2S,2'S)-bis(2,6-bis[(tert-butoxycarbonyl)amino]hexanoate) 
• 1229002-42-9 (2S)-3-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{[(tert-butoxycarbonyl)amino]acetate} 
• 1229002-43-0 (2S)-3-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{5-[(tert-butoxycarbonyl)amino]pentanoate} 
• 1229002-60-1 C₄₈H₅₈ClN₇O₁₀S 
• 1229002-41-8 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2S,2'S)-bis{2-[(tert-butoxycarbonyl)amino]propanoate} 
• 1229002-46-3 (2S)-3-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{3-[(tert-butoxycarbonyl)amino]propanoate} 
• 1229002-49-6 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2R,2'R)-bis{2-[(tert-butoxycarbonyl)amino]propanoate} 
• 1229002-54-3 (2S)-3-{4-[2-Amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl bis{4-[(tert-butoxycarbonyl)amino]butanoate} 
• 1229002-45-2 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2S,2'S)-bis{2,4-bis[(tert-butoxycarbonyl)amino]butanoate} 
• 1229002-56-5 (2S)-3-{4-[2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulphanyl)-3,5-dicyanopyridin-4-yl]phenoxy}propane-1,2-diyl (2S,3R,2'S,3R)-bis{3-tert-butoxy-2-[(tert-butoxycarbonyl)amino]butanoate} 
• 1229002-59-8 C₄₆H₅₄ClN₇O₁₀S 

Relevant academic research and scientific papers

AMINO ACID ESTER PRODRUGS AND THE USE THEREOF

The present application relates to amino acid ester prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitriles, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.

SUBSTITUTED ARYLOXAZOLES AND THEIR USE

The present application relates to novel substituted aryloxazole derivatives, a method for the production thereof, the use thereof for the treatment and/or prophylaxis of diseases and the use thereof for the production of drugs for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular and metabolic disorders.

DIPEPTOID PRODRUGS AND THE USE THEREOF

The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.