1107664-89-0Relevant academic research and scientific papers
Stereocontrolled synthesis of enantiopure cis- and trans-3,4,4a,5,8,8a-hexahydro-1H-quinolin-2-ones
Amat, Mercedes,Perez, Maria,Minaglia, Annamaria T.,Passarella, Daniele,Bosch, Joan
experimental part, p. 2406 - 2410 (2009/04/06)
Starting from the 8-allyl substituted oxazolopiperidone lactam 2b, which is easily accessible from (R)-phenylglycinol and racemic δ-oxoester 1a, two-step sequences involving a stereoselective α-amidoalkylation reaction, either with inversion or retention of configuration, followed by a ring-closing metathesis, provide diastereodivergent routes to enantiopure cis- and trans-3,4,4a,5,8,8a-hexahydro-1H-quinolin-2-ones.
