110794-89-3Relevant academic research and scientific papers
Synthese d'alkenyl-4 dialkyl-2,4 dialkylaminocarbonyl-3 butanolides-4 au moyen d'organozinciques allyliques
Mladenova, Margarita,Gaudemar-Bardone, Francoise,Simova, Svetlana,Couffignal, Rene
, p. 479 - 485 (2007/10/02)
3-Acyl-2-alkyl-3-dialkylaminocarbonylpropanoic acids 1 are easily prepared from β-ketoamides and α-brominated acids.Treatment of the acids 1 with allylzinc derivatives leads to a new series of 3-dialkylaminocarbonyl-4-butanolides 2 containing an alkene substituent in position 4.The reaction proceeds with good stereoselectivity affording the substituents with cis stereochemistry in position 3-4 of the lactone ring.
