110797-47-2Relevant academic research and scientific papers
Building Units of Oligosaccharides, LXXXVI1). - Glycosidation with Thioglycosides of Oligosaccharides to Segments of O-Glycoproteins.
Paulsen, Hans,Rauwald, Wolfgang,Weichert, Udo
, p. 75 - 86 (2007/10/02)
In the presence of dimethyl(methylthio)sulfonium triflate (DMTST) thioglycosides of mono-, di-, tri-, and tetrasaccharides, which contain a 2-azido-2-deoxy-D-galactose as reducing unit, can react with the hydroxy group of selectively blocked derivatives of L-serine.These reactions yield the corresponding O-glycosides.Preferentially the α-glycosidically bound products will be obtained.In this way the trisaccharide glycoside 46 was prepared, which represents the core-II structure of mucins α-glycosidically linked to L-serine.Methyl triflate as promoter of this thioglycosidation is less efficient than DMTST.
