110808-69-0

Basic information

• Product Name: 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE
• Synonyms: 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE;1-Naphthalenecarbonyl chloride, 5,6,7,8-tetrahydro- (9CI);5,6,7,8-Tetrahydro-1-naphthalenecarbonyl chloride;5,6,7,8-Tetrahydronaphthalene-1-carboxylic acid chloride;1-NAPHTHALECARBONYL CHLORIDE, 5,6,7,8-TETRAHYDRO
• CAS NO: 110808-69-0
• Molecular Formula: C₁₁H₁₁ClO
• Molecular Weight: 194.65744
• Product Categories: ACIDHALIDE
• Mol File: 110808-69-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 312.8±31.0 °C(Predicted)
• Appearance: /
• Density: 1.196
• CAS DataBase Reference: 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE(110808-69-0)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDRO-NAPHTHALENE-1-CARBONYL CHLORIDE(110808-69-0)

Safety Data

• Hazardous Substances Data: 110808-69-0(Hazardous Substances Data)

Usage

Uses

5,6,7,8-Tetrahydronaphthalene-1-carbonyl Chloride is used in the synthesis of a sweetening agent, N-5,6,7,8-Tetrahydro-1-naphthoyl-α-L-glutamyl-5-amino-2-pyridine carbonitrile.

Upstream product

• 4242-18-6 5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid 

Downstream Products

• 135729-78-1 N-<(S)-1-azabicyclo<2.2.2>oct-3-yl>-5,6,7,8-tetrahydronaphthalene-1-carboxamide 
• 135755-51-0 palonosetron hydrochloride 
• 274929-58-7 N-[2-(4-chlorophenyl)-4-hydroxybutyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide 
• 274929-51-0 N-[2-(3,4-Difluorophenyl)-4-hydroxybutyl]-N-methyl-5,6,7,8-tetrahydro-1-naphthamide 
• 858198-73-9 5-[1-(2-chloro-phenyl)-vinyl]-1,2,3,4-tetrahydro-naphthalene 
• 110424-25-4 3-phenyl-2,3,6,7,8,9-hexahydro-1H-cyclopenta[a]naphthalene 
• 109690-71-3 3t-phenyl-1-(5,6,7,8-tetrahydro-[1]naphthyl)-propenone 
• 110937-79-6 3-phenyl-2,3,6,7,8,9-hexahydro-cyclopenta[a]naphthalen-1-one 
• 135729-60-1 palonosetron 
• 135729-60-1 palonosetron 
• 135729-56-5 (S)-2-(1-azabicyclo[2.2.2]oct-3-yl)-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one 
• 14935-18-3 5,6-Dihydro-1H,4H-naphto[1,8-cd]pyran-1-one 
• 860372-50-5 (2-chloro-phenyl)-(5,6,7,8-tetrahydro-[1]naphthyl)-ketone 
• 13577-40-7 1-(5,6,7,8-tetrahydro-naphthalen-1-yl)-ethanone 

Relevant articles and documents

Total synthesis of RS-42358 and analogs using lateral lithiation

A short synthesis of the 5-HT3 receptor antagonist RS-42358 was developed based on the condensation of lactone 2 with S-3- aminoquinuclidine. The position 2 analogs of RS-42358 were made by condensing various primary amines with lactone 2. The key step in the synthesis of lactone 2 was lateral lithiation of diethyl amide 7 using n-BuLi in THF.

N-Heterocyclic-Carbene-Catalyzed C–H Acylation via Radical Relay

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Heterocyclic compound and preparation and application thereof

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