110808-77-0Relevant academic research and scientific papers
Novel guanidinobenzamides
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, (2008/06/13)
Compounds of formula IA and IB are new where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical form
Axial/equatorial populations in α-hetero-substituted cyclohexanone oximes and O-methyl oximes
Ribeiro, Douglas S.,Olivato, Paulo R.,Rittner, Roberto
, p. 627 - 638 (2007/10/03)
Axial equatorial populations were determined for (E)-2-X-cyclohexanone oximes and O-methyl oxime ethers in chloroform by the Eliel method [X = F, Cl, Br, OCH3, N(CH3)2, SCH3]. A novel approach is presented, whic
Stereoselective hydride reductions of cyclic N-diphenylphosphinyl imines. Highly diastereoselective syntheses of protected primary amines
Hutchins,Adams,Rutledge
, p. 7396 - 7405 (2007/10/03)
Reduction of N-diphenylphosphinyl imines of variously substituted cyclohexanones, cyclopentanones, and bicyclic ketones with lithium tri-sec-butylborohydride provides highly diastereoselective procedures for the syntheses of N-diphenylphosphinyl amines which represent protected primary amines that can be unmasked by mild acidic cleavage. Attack of cyclohexyl derivatives occurs almost exclusively via equatorial approach to yield axial amine derivatives while cyclopentyl and bicyclic imines are attacked from the less sterically encumbered faces.
Efficient Functional Group Transformations on a Cyclic Nitroalkene System
Hwu, Jih Ru,Wang, Naelong
, p. 427 - 428 (2007/10/02)
Single-pot nitroalkene -> cyanoaldehyde transformation, α-methoxy oxime formation, α- and β-alkylations of β-sulphenylated nitro compound, generation of β-sulphenylated nitro compound, generation of β-sulphenylated silyl nitronate, and sequential Michael addition and Nef reaction have been accomplished in good to excellent yields.
