1108084-55-4Relevant academic research and scientific papers
Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine
Yang, Yi-Chi,Lin, Yi-Ching,Wu, Yen-Ku
, p. 9286 - 9290 (2019)
Described is a method for the transformation of a cyclic vinylogous ester to the corresponding polyarylated product. We found a catalytic system comprising palladium diacetate and tris(1-adamantyl)phosphine is quite effective in promoting a set of control
Palladium-catalyzed asymmetric direct intermolecular allylation of α-aryl cyclic vinylogous esters: Divergent synthesis of (+)-oxomaritidine and (?)-mesembrine
Wang, Wei,Dai, Jun,Yang, Qiqiong,Deng, Yu-Hua,Peng, Fangzhi,Shao, Zhihui
supporting information, p. 920 - 924 (2021/02/16)
We demonstrate that α-aryl cyclic vinylogous esters are competent substrates in the direct intermolecular Pd-catalyzed asymmetric allylic alkylation, enabling a straightforward enantioselective synthesis of 6-allyl-6-aryl-3-ethoxycyclohex-2-en-1-ones, common motifs embedded in numerous structurally diverse natural products. As an initial demonstration of the utility of this protocol, the first catalytic enantioselective total synthesis of (+)-oxomaritidine and an improved five-step catalytic enantioselective synthesis of (?)-mesembrine have been completed divergently.
Palladium-catalyzed sequential arylation and allylic alkylation of highly functionalized ketones: A concise synthesis of mesembrine
Zhao, Yuanhong,Zhou, Yongyun,Liang, Leilei,Yang, Xiaodong,Du, Fengxiang,Li, Ang,Zhang, Hongbin
supporting information; experimental part, p. 555 - 558 (2009/07/25)
(Chemical Equation Presented) An unprecedented palladium-catalyzed sequential procedure toward arylation and allylic alkylation of highly functionalized cyclohexenones was developed. This new protocol leads to useful building blocks containing a benzylic
