1108149-27-4Relevant academic research and scientific papers
Synthesis, structure, and cholinergic effect of novel neuroprotective compounds bearing the tacrine pharmacophore
Hamul'akova, Slavka,Kristian, Pavol,Jun, Daniel,Kuca, Kamil,Imrich, Jan,Danihel, Ivan,Boehm, Stanislav,Klika, Karel D.
, p. 1219 - 1235 (2008)
Novel tacrine congeners with side ligands suitable for optimal interaction with the peripheral and catalytic sites of acetyl- and butyrylcholinesterase (AChE and BuChE) have been synthesized using either 9-isothiocyanato-1,2,3,4-tetrahyhroacridine or 9-chloro-1,2,3,4-tetrahydroacridine which represent convenient synthons by reaction with various substituted amines. The synthesized compounds were tested for their inhibition of AChE and BuChE whereby a morpholine and a furfuryl derivative were found to be the most potent AChE and BuChE inhibitors, respectively, with the latter compound comparable in activity to tacrine.
