1108168-65-5Relevant articles and documents
A new linker for solid-phase synthesis of oligonucleotides with terminal phosphate group
Paces, Ondrej,Tocik, Zdenek,Rosenberg, Ivan
, p. 32 - 43 (2008/12/22)
Synthesis of a novel cyanoethyl-type linker suitable for the solid-phase synthesis of oligodeoxynucleotides possessing terminal 3′-phosphate group is described. Since the linker is a 2-substituted 2-cyanoethanol, the release of the synthesized oligonucleotide from the solid support is accomplished by β-elimination in the ammonia deprotection step. 2008 Institute of Organic Chemistry and Biochemistry.
