1108171-35-2Relevant academic research and scientific papers
Efficient and flexible solid-phase synthesis of N-hydroxypolyamine derivatives
Meret, Michael,Bienz, Stefan
, p. 5518 - 5525 (2008)
Orthogonally protected, N-hydroxylated, linear tri- and tetra-amines were efficiently synthesised on Merrifield resin, which was modified with a phenethyl bromide linker. The polyamine frameworks were convergently prepared from the centre with reductive aminations and nucleophilic substitutions to elongate the polyamine backbone. The required N-hydroxy groups were introduced during the cleavage of the polyamine derivatives from the resin through Cope elimination. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
