1108185-05-2Relevant academic research and scientific papers
Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones as MCH-1 antagonists for the treatment of obesity
Hadden, Mark,Deering, Dustin M.,Henderson, Alan J.,Surman, Matthew D.,Luche, Michele,Khmelnitsky, Yuri,Vickers, Steven,Viggers, Jean,Cheetham, Sharon,Guzzo, Peter R.
scheme or table, p. 7020 - 7023 (2010/12/25)
A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties. Selected compounds were studied in a five-day diet induced obese mouse model to evaluate their potential use as weight loss agents.
