1108192-19-3

Basic information

• Product Name: 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene
• Synonyms: 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene
• CAS NO: 1108192-19-3
• Molecular Formula: C18H33BrO2Si2
• Molecular Weight: 417.52842
• Mol File: 1108192-19-3.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Solubility: DCM
• CAS DataBase Reference: 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene(1108192-19-3)
• EPA Substance Registry System: 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene(1108192-19-3)

Safety Data

• Hazardous Substances Data: 1108192-19-3(Hazardous Substances Data)

Usage

Description

4-Bromo-1,2-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzene is a complex organic compound characterized by a benzene ring with a bromine atom at the 4-position and two dimethylsilyl ether groups attached to the 1 and 2 positions. 4-BroMo-1,2-bis[[(1,1-diMethylethyl)diMethylsilyl]oxy]benzene is known for its unique structural features and serves as a crucial intermediate in the synthesis of various organic compounds.

Uses

Used in Pharmaceutical Industry:
4-Bromo-1,2-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzene is used as an intermediate in the synthesis of metabolite of (-)-Epicatechin (E582260) for its potential therapeutic applications. This intermediate plays a vital role in the development of new drugs and pharmaceutical agents, contributing to the advancement of medicine and healthcare.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Bromo-1,2-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzene is utilized as a key building block for the creation of more complex organic molecules. Its unique structure allows for various chemical reactions, enabling the synthesis of a wide range of compounds with diverse applications in different industries.
Used in Chemical Research:
4-Bromo-1,2-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzene is also employed in chemical research for studying the properties and reactivity of complex organic molecules. Its use in research helps scientists gain a deeper understanding of chemical reactions and mechanisms, ultimately leading to the discovery of new compounds and applications.

Upstream product

• 1761-61-1 5-bromosalicyclaldehyde 
• 120-80-9 benzene-1,2-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 2859-78-1 4-Bromoveratrole 
• 17345-77-6 1-bromo-3,4-dihydroxybenzene 

Downstream Products

• 1354453-73-8 8-(3'',4''-dihydroxyphenyl)-2'-deoxyguanosine 

Relevant articles and documents

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways

Identification and validation of the targets of bioactive small molecules identified in cell-based screening is challenging and often meets with failure, calling for the development of new methodology. We demonstrate that a combination of chemical proteom

Conjugated Metal-Organic Macrocycles: Synthesis, Characterization, and Electrical Conductivity

The dimensional reduction of solids into smaller fragments provides a route to achieve new physical properties and gain deeper insight into the extended parent structures. Here, we report the synthesis of CuTOTP-OR (TOTPn- = 2,3,6,7-tetraoxidotriphenylene), a family of copper-based macrocycles that resemble truncated fragments of the conductive two-dimensional (2D) metal-organic framework Cu3(HHTP)2 (HHTP = 2,3,6,7,10,11-hexahydroxytriphenylene). The planar metal-organic macrocycles self-assemble into ordered nanotubes with internal diameters of ～2 nm and short interlayer distances of ～3.20 ?. Strong π-πstacking interactions between macrocycles facilitate out-of-plane charge transport, and pressed pellet conductivities as high as 2(1) × 10-3 S cm-1 are observed. Peripheral alkyl functionalization enhances solution processability and enables the fabrication of thin-film field-effect transistor devices. Ambipolar charge transport is observed, suggesting that similar behavior may be operative in Cu3(HHTP)2. By coupling the attractive features of metal-organic frameworks with greater processability, these macrocycles enable facile device integration and a more nuanced understanding of out-of-plane charge transport in 2D conductive metal-organic frameworks.

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Recently, the steroidal CYP17 inhibitor Abiraterone entered phase II clinical trial for the treatment of androgen-dependent prostate cancer. As 17α-hydroxylase-17,20-lyase (CYP17) catalyzes the last step in androgen biosynthesis, inhibition of this target should affect not only testicular but also adrenal androgen formation. Therefore CYP17 inhibitors should be advantageous over existing therapies, for example with GnRH analogues. However, steroidal drugs are known for side effects which are due to affinities for steroid receptors. Therefore we decided to synthesize non-steroidal compounds mimicking the natural CYP17 substrates pregnenolone and progesterone. The synthesis and biological evaluation of a series of 15 novel and highly active non-steroidal CYP17 inhibitors are reported. The compounds were prepared via Suzuki-cross-coupling, Grignard reaction and CDI-assisted SNt-reaction with imidazole and their inhibitory activity was examined with recombinant human CYP17 expressed in Escherichia coli. Promising compounds were further tested for their selectivity against the hepatic enzyme CYP3A4 and the glucocorticoid-forming enzyme CYP11B1. All compounds turned out to be potent CYP17 inhibitors. The most active compounds 7 and 8 were much more active than Ketoconazole showing activity comparable to Abiraterone (IC50 values of 90 and 52 nM vs. 72 nM). Most compounds also showed higher selectivities than Ketoconazole, but turned out to be less selective than Abiraterone. Docking studies using our CYP17 protein model were performed with selected compounds to study the interactions between the inhibitors and the amino acid residues of the active site.