1108205-34-0

Upstream product

• 120343-66-0 (R)-1-(1-phenylethyl)tetrahydro-4(1H)-pyridinone 
• 874-42-0 2,4-dichlorobenzaldeyhde 

Downstream Products

• 1245653-93-3 (5R,6R,10S)-10-(2,4-dichlorophenyl)-14-[(E)-1-(2,4-dichlorophenyl)methylidene]-3,9-di(4-isopropylphenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1245653-76-2 (5S,6S,10R)-10-(2,4-dichlorophenyl)-14-[(E)-1-(2,4-dichlorophenyl)methylidene]-3,9-di(4-isopropylphenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1245654-03-8 (4R,5S,6R,11R,15S)-4,15-bis(2,4-dichlorophenyl)-3,9,14-tri(4-isopropyl-phenyl)-17-(1-phenylethyl)-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.0.4.3]-octadeca-2,8,13-triene 
• 1245653-91-1 (5R,6R,10S)-10-(2,4-dichlorophenyl)-14-[(E)-(2,4-dichlorophenyl)methylidene]-3,9-diphenyl-12-[(R)-1-phenylethyl]-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1108205-32-8 (5S,6S,10R)-10-(2,4-dichlorophenyl)-14-[(E)-(2,4-dichlorophenyl)methylidene]-3,9-diphenyl-12-[(R)-1-phenylethyl]-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1245654-01-6 (4R,5S,6R,11R,15S)-4,15-bis(2,4-dichlorophenyl)-3,9,14-triphenyl-17-[(R)-1-phenylethyl]-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.0.4.3]octadeca-2,8,13-triene 
• 1245653-92-2 (5R,6R,10S)-3,9-bis(4-chlorophenyl)-10-(2,4-dichlorophenyl)-14-[(E)-(2,4-di-chlorophenyl)methylidene]-12-[(R)-1-phenylethyl]-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1245653-75-1 (5S,6S,10R)-3,9-bis(4-chlorophenyl)-10-(2,4-dichlorophenyl)-14-[(E)-(2,4-di-chlorophenyl)methylidene]-12-[(R)-1-phenylethyl]-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene 
• 1245654-02-7 (4R,5S,6R,11R,15S)-3,9,14-tris(4-chlorophenyl)-4,15-bis(2,4-dichloro-phenyl)-17-[(R)-1-phenylethyl]-1,7,10,12-tetraoxa-2,8,13,17-tetraazatrispiro[4.0.4.0.4.3]octadeca-2,8,13-triene 

Relevant academic research and scientific papers

1,3-Dipolar cycloaddition of nitrile oxides to (R)-1-(1-phenylethyl)-3,5- bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of novel enantiomerically pure di- and trispiroheterocycles

Enantiomerically pure (R)-(1-phenylethyl)-3,5-bis[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones were synthesized for the first time, and their 1,3-dipolar cycloaddition with nitrile oxides affording di- and trispiroheterocycles regio- and stereoselectively in moderate yields was investigated. These compounds were evaluated against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug-resistant M. tuberculosis (MDR-TB). Among the compounds screened, the dispiroheterocycle, namely, (5R,6R,10S)-3,9-bis(4- chlorophenyl)-10-(2,4-dichlorophenyl)-14-[(E)-(2,4-dichlorophenyl)methylidene] -12-[(R)-1-phenylethyl]-1,4,7-trioxa-2,8,12-tri-azadispiro[4.0.4.4]tetradeca-2, 8-diene 5m was found to possess the maximum activity with MIC of 0.49 μM against MTB, being 9.6 and 15.6 times more potent than ciprofloxacin and ethambutol, respectively. Against MDR-TB, 5m displayed maximum activity with an MIC of 0.49 μM, with it thus being more active than rifampicin, isoniazid, ciprofloxacin and ethambutol by 7.8, 23, 77 and 124 times, respectively.