110829-97-5

Upstream product

• 90-59-5 3,5-Dibromosalicylaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 1377688-71-5 (E)-3-(3,5-dibromo-2-(2,6-dinitro-4-(trifluoromethyl)phenoxy)phenyl)-1-(4-methoxyphenyl)prop-2-en-1-one 
• 1398523-27-7 C₁₈H₁₆Br₂N₂O₃ 
• 1071701-50-2 C₁₆H₁₄Br₂N₂O₂ 
• 1435462-18-2 1-(5-(3,5-dibromo-2-(2,6-dinitro-4-(trifluoromethyl)-phenoxy)phenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone 
• 1537909-65-1 C₂₃H₁₅Br₂F₃N₄O₆ 
• 101081-36-1 6,8-dibromo-3-hydroxy-2-(4-methoxy-phenyl)-chromen-4-one 
• 133131-58-5 6,8-dibromo-2-(4-methoxy-phenyl)-chroman-4-one 

Relevant academic research and scientific papers

6, 8-dibromobenzopyran derivative and application thereof in pesticide

The invention relates to a 6, 8-dibromobenzopyran derivative and application thereof in pesticides, and belongs to the technical field of pesticides. The technical problem to be solved by the invention is to provide the 6, 8-dibromobenzopyran derivative which can be used as an insecticide and a bactericide. The structural general formula of the benzopyran compound is shown as a formula I, and R is a hydrogen atom, a halogen atom, a C1-C4 alkyl group or a C1-C4 alkoxy group. The compound disclosed by the invention is simple in synthesis process, has a relatively good poisoning effect on pests, has a relatively good inhibition effect on plant pathogenic bacteria, and lays a relatively good foundation for creation of novel pesticides.

Design, Synthesis, Biological Evaluation, and Molecular Modeling of Novel 4H-Chromene Analogs as Potential Succinate Dehydrogenase Inhibitors

Thirty-one new 4H-chromene derivatives were designed and synthesized. Their structures were identified with IR,1H NMR,13C NMR, and HRMS. The crystal structure of compound2awas determined by single-crystal X-ray diffraction. Their ant

Synthesis, and antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives as DNA gyrase inhibitors

A series of novel 4,5-dihydropyrazole derivatives (4a-4t), containing the dinitrobenzotrifluoride moiety, as DNA gyrase inhibitors were designed and synthesized. Based on the preliminary results, compounds 4d, 4h and 4t with potent inhibitory activity in

Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors

A series of novel 4,5-dihydropyrazole derivatives (3a-3t) containing hydroxyphenyl moiety as potential V600E mutant BRAF kinase (BRAF V600E) inhibitors were designed and synthesized. Docking simulation was performed to insert compounds 3d (1-(5-(5-chloro-2-hydroxyphenyl)-3-(p- tolyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone) and 3m (1-(3-(4-chlorophenyl)-5-(3, 5-dibromo-2-hydroxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone) into the crystal structure of BRAFV600E to determine the probable binding model, respectively. Based on the preliminary results, compound 3d and 3m with potent inhibitory activity in tumor growth may be a potential anticancer agent. Results of the bioassays against BRAFV600E, MCF-7 human breast cancer cell line and WM266.4 human melanoma cell line all showed several compounds had potent activities IC50 value in low micromolar range, among them, compound 3d and compound 3m showed strong potent anticancer activity, which were proved by that 3d: IC50 = 1.31 μM for MCF-7 and IC50 = 0.45 μM for WM266.5, IC50 = 0.22 μM for BRAFV600E, 3m: IC50 = 0.97 μM for MCF-7 and IC50 = 0.72 μM for WM266.5, IC50 = 0.46 μM for BRAFV600E, which were comparable with the positive control Erlotinib.

Design, synthesis and biological evaluation of novel chalcone derivatives as antitubulin agents

A series of novel chalcone derivatives have been designed and synthesized, and their biological activities were also evaluated as potential inhibitors of tubulin. These compounds were assayed for growth-inhibitory activity against MCF-7 and A549 cell line