110830-17-6

Basic information

• Product Name: 5-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-2-THIOXODIHYDRO-1H-IMIDAZOL-4-ONE
• Synonyms: 5-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-2-THIOXODIHYDRO-1H-IMIDAZOL-4-ONE;(5Z)-5-[(2H-1,3-benzodioxol-5-yl)methylidene]-2-sulfanylideneimidazolidin-4-one
• CAS NO: 110830-17-6
• Molecular Formula: C₁₁H₈N₂O₃S
• Molecular Weight: 248.26
• Mol File: 110830-17-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-2-THIOXODIHYDRO-1H-IMIDAZOL-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-2-THIOXODIHYDRO-1H-IMIDAZOL-4-ONE(110830-17-6)
• EPA Substance Registry System: 5-[(Z)-1,3-BENZODIOXOL-5-YLMETHYLIDENE]-2-THIOXODIHYDRO-1H-IMIDAZOL-4-ONE(110830-17-6)

Safety Data

• Hazardous Substances Data: 110830-17-6(Hazardous Substances Data)

Upstream product

• 495-76-1 piperonol 
• 503-87-7 2-thiohydantoin 
• 120-57-0 piperonal 
• 32085-04-4 3-acetyl-2-thioxoimidazolidin-4-one 

Downstream Products

• 1112978-28-5 (5Z)-5-(1,3-benzodioxol-5-ylmethylidene)-2-methylsulfanyl-3,5-dihydro-4H-imidazol-4-one 
• 1402230-97-0 (5Z)-2-[4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one 
• 1430324-81-4 (5Z)-2-[4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one 
• 1402230-96-9 (5Z)-2-[4-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]phenylamino]-5-(benzo[1,3]dioxol-5-ylmethylene)-3,5-dihydroimidazol-4-one 

Relevant articles and documents

Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation

Leucettamine B is a natural product found in marine sponge Leucetta microraphis. Several of analogs of its family, such as aplysinopsine and clathridine, are medicinally active molecules which have applications in many pharmaceuticals and healthcare products; however, thus far, leucettamine B has not been studied. In this report, we describe the synthesis of a new class of analogs of leucettamine B obtained by Knoevenagel condensation using a microwave reactor. The 25 newly synthesized compounds were tested against MDA-MB-468, SW480, and Mahlavu cell lines for anticancer activity. Among them, the carborane-based compound (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)-3-(1-closo-carboranyl)-2-thioxo -thiazolidin-4-one (49) and (Z)-5-(benzo[d][1,3]dioxol-5-ylmethylene)-3-(2-(pyrrolidin-1-yl)ethyl)-2-thioxothiazolidin-4-one (31) derivatives were found to have the most potential for use against tumor cells. The carborane derivative 49 had the lowest IC50 value against the SW480 cell line (4.7 μM) and the Mahlavu (6.6 μM) cell line. Furthermore, compound 31 also had a low IC50 value against SW480 (7.5 μM). Our research shows that leucettamine B analogs might have potential for use in cancer chemotherapy.

USE OF HETEROCYCLIC DERIVATIVES WITH CARDIOMYOCYTE PROLIFERATION ACTIVITY FOR TREATMENT OF HEART DISEASES

Provided herein is the use of heterocyclic derivatives with cardiomyocyte proliferation activity for treatment of heart diseases. Specifically, disclosed is the use of compounds of formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a prodrug thereof; and application thereof. Definition of each group in the formula can be found in the specification for details.

Microwave-Assisted condensation reactions of acetophenone derivatives and activated methylene compounds with aldehydes catalyzed by boric acid under solvent-free conditions

We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally