110841-84-4Relevant academic research and scientific papers
Synthesis method of nickel-catalyzed C - 3 alkyl substituted quinoxalinone under electrochemical condition
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Paragraph 0006; 0059-0062, (2021/04/10)
The invention discloses a method for synthesizing C-3 alkyl substituted quinoxalinone by nickel catalysis under an electrochemical condition, and belongs to the technical field of preparation of compounds. The method comprises the steps: taking 2-hydroxyq
Regioselective syntheses of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones from arylglycidates when exposed to 1,2-diaminobenzenes
Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Voronina, Julia K.,Mahrous, Essam M.,Korshin, Dmitry E.,Latypov, Shamil K.,Sinyashin, Oleg G.
, (2020/09/10)
Representatives of two pharmacologically significant classes of compounds – 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones and 3-benzylquinoxalin-2(1H)-ones – obtained in reactions of 1,2-diaminobenzenes with methyl 3-arylglycidates in boiling acetic acid. Substituents in arylglycidates determine the direction of processes. Electron withdrawing substituents (NO2), halogen atoms (Cl, Br, F), as well as the absence of substituents, provide the formation of benzo[b][1,4]diazepin-2(1H)-one derivatives, and electron donating groups (OMe, Me) contribute to the formation of 3-benzylquinoxalin-2(1H)-ones. As a result, a new rare representatives of 3-hydroxy-4-aryl-3,4,5-trihydro-2H-benzo[b][1,4]diazepin-2(1H)-ones were obtained and a new method for producing 3-benzylquinoxalin-2(1H)-ones has been proposed.
Nickel-catalyzed electrochemical reductive decarboxylative coupling of: N -hydroxyphthalimide esters with quinoxalinones
Lian, Fei,Xu, Kun,Meng, Wei,Zhang, Haonan,Tan, Zhoumei,Zeng, Chengchu
, p. 14685 - 14688 (2019/12/11)
Herein the first example of electrochemically enabled, NiCl2-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxylative coupling allows access to structurally diverse 3-alkylated quinoxalinones in up to 91% yields.
Microwave-assisted solvent-dependent reaction: Chemoselective synthesis of quinoxalin-2(1 H)-ones, benzo[ d]imidazoles and dipeptides
Wang, Shu-Liang,Ding, Jie,Jiang, Bo,Gao, Yuan,Tu, Shu-Jiang
supporting information, p. 572 - 577 (2011/11/06)
A microwave-assisted solvent-dependent chemoselective reaction dealing with 4-arylidene-2-phenyloxazol-5-ones and diverse ortho-diamines to achieve three types of molecular scaffolds, 3-benzylquinoxalin-2(1H)-ones, benzimidazole and β-amino dipeptides is
Condensation of o-Phenylenediamines with Azlactones
Subhashini, N. J. Prameela,Hanumanthu, P.
, p. 32 - 35 (2007/10/02)
Condensation of o-phenylenediamines (I) with 4-arylidene-2-substituted-oxazolin-5-ones (II) (azlactones) in acetic acid results in the formation of 3-benzyl-2(1H)quinoxalinones (III) and substituted benzimidazoles (IV).Structures of these compounds have been established based on their spectral data, and direct comparison with authentic samples prepared by unambiguous routes.
