110859-23-9

Upstream product

• 110858-76-9 4-(2-hydroxyethylamino)-2-methyl-6,7-dihydropyrimido<5,4-b><1,4>oxazin-7(8H)-one 
• 100-44-7 benzyl chloride 
• 110858-68-9 4-[N-benzyl-N-(2-hydroxyethyl)]-amino-2-methyl-6-7-dihydro-8H-pyrimido[5,4-b][1,4]oxazin-7-one 

Relevant academic research and scientific papers

Synthesis and positive inotropic activity of novel pyrimido-[5,4-b][1,4]oxazin-7(8H)-ones

Seventy-five compounds I were synthesized and tested for positive inotropic activity. Some derivatives (22, 24, 54) showed an activity comparable to that of amrinone. Compound 24 was selected for preclinical study. According to the biochemical and pharmacological data its activity may involve a novel mechanism(s).

Pyrimido[5,4-B][1,4]oxazine derivatives and pharmaceutical compositions containing them

The invention relates to novel pyrimido [5,4-b][1,4]oxazine derivatives of the formula (I), and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) STR1 wherein R1