110862-13-0Relevant academic research and scientific papers
1-(3,4-dimethylbenzyl)-2-(N-alkyl)-carbamoyl tetrahydroiso quinolines
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, (2008/06/13)
Compounds of the Formula (I) STR1 wherein R1 and R2 are hydroxyl or methoxyl; R3 is hydrogen or methoxyl; and R4 is methyl or chloroethyl; are disclosed having the ability to inhibit adenylatecyclase.
Synthesis and antiglaucomic activity of N-carbamoyl derivatives of trimethoquinol
Ivanov,Panova,Berova,et al.
, p. 45 - 48 (2007/10/02)
The synthesis of a new type of β-adrenergic blocker 1a was obtained by incorporation of a 2-chloroethylcarbamoyl group into the selective β-adrenergic agonist trimethoquinol (S) (-). The new compound 1a inhibited β-receptor associated adenylate cyclase and lowered the intraocular pressure in rabbits. β-receptor blocking activity is probably due to receptor alkylation. This is proved by the synthesis and investigation of two model compounds that either have no OH groups in ring A or chloroethylcarbamoyl group in ring B.
