110871-22-2Relevant academic research and scientific papers
The Reduction of β-Iminoketones
Armesto, Diego,Perez-Ossorio, Rafael,Plumet, Joaquin,Ramos, Ana
, p. 901 - 914 (2007/10/02)
The reduction of N-substituted 3-imino-2,2-dimethyl-1-phenylpropan-1-ones and N-substituted 3-imino-2,2-dimethyl-1-phenylbutan-1-ones is reported.Catalytic hydrogenation with palladium led mainly to the related aminoketones in the case of the propanone derivatives.No reduction was observed for butanone derivatives.Both propanone and butanone derivatives were reduced to the related aminoalcohols by lithium aluminium hydride, the reaction being highly stereoselective in the latter case.When using sodium borohydride as the reducing agent, fragmentation was observed with the formation of mixtures of products from which, in favourable cases, benzyl alcohol and N-substituted alkyl amines were isolated.All of these results are discussed and interpreted.
