1108725-35-4

Upstream product

• 644950-37-8 N-methyl-1-(4-methyl-1,3-thiazol-2-yl)methaneamine 
• 439937-35-6 C₉H₆BrClO₃ 
• 161796-10-7 3-bromo-5-(methoxycarbonyl)benzoic acid 

Downstream Products

• 1221350-28-2 5-bromo-N-methyl-N-(4-methyl-thiazol-2-ylmethyl)-isophthalamic acid 

Relevant academic research and scientific papers

ASPARTYL PROTEASE INHIBITORS

A compound of formula (I) N-oxides, addition salts, quaternary amines metal complexes stereochemically isomeric forms and metabolites thereof, wherein A is CR1 Or N; formula (A) or formula (B) D is H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, G is NR10 or O Q is C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6Cycloalkyl, aryl or heterocyclyl; W is H, C1-C6alkyl, C3-C6Cycloalkyl, CH2F, CHF2 or CF3; one of X' and X" is H or CH3, the other is C1-C3alkyl, F, OH, NRaRb, CF3 or N3; or X' and X" are both F; Y is NRd or O; Z is O, NRa, CHRd, CF2 or S(=0)r or a bond; the other variables are as defined in the specification. The compounds of the invention are inhibitors of BACE and are among other things useful for the treatment and/or prevention of conditions associated with BACE activity such as Alzheimer's disease.

ASPARTYL PROTEASE INHIBITORS

A compound of formula (I): N-oxides, addition salts, quaternary amines metal complexes stereochemically isomeric forms and metabolites thereof, wherein A is CR1 or N; D is H, C1-C6alkyl, C2-C6alkenyl,