1108743-08-3Relevant academic research and scientific papers
A short and efficient synthesis of 3-spiro-α-methylene-γ- butyrolactone oxindolones from isomerised bromo derivatives of Morita-Baylis-Hillman adducts
Shanmugam, Ponnusamy,Viswambharan, Baby
, p. 2763 - 2768 (2008)
A short and efficient synthesis of α-methylene-γ-butyrolactone- 3-spirooxindolones by the reaction of isomerised bromo derivatives of Morita-Baylis-Hillman adducts of isatin and formaldehyde followed by acid-catalysed lactonisation has been achieved. The oxindolidino allyl bromide has been used for the first time for the allylation of aldehydes to afford a 2-oxindolidino homoallylic alcohol which on acid-catalysed lactonisation delivered the title compounds in excellent yield. Synthetic transformation of the spirolactone oxindole is demonstrated with the preparation of an oxirane derivative and a second Morita-Baylis-Hillman adduct. Georg Thieme Verlag Stuttgart.
