1108791-75-8

Upstream product

• 1108600-49-2 (1S,5R)-6-(p-nitrobenzenesulfonyl)-6-azabicyclo[3.2.0]hept-3-en-7-one 
• 1108600-48-1 tetrabutylammonium 2,6-dichloropurin-9-ide 

Downstream Products

• 1108600-51-6 (1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)-N-methyl-N-(4-nitrophenylsulfonyl)cyclopent-2-enecarboxamide 

Relevant academic research and scientific papers

PREPARATION OF SYNTHETIC NUCLEOSIDES VIA π-ALLYL TRANSITION METAL COMPLEX FORMATION

This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises a) preparing a bicycloamide derivative, b) reacting the bicycloamide derivative with a nucleic acid base or heterocyclic base or salt thereof in the presence of a transition metal catalyst to form a cyclopentenecarboxamide, and c) cleaving a carboxamide group from the cyclopentenecarboxamide to form the synthetic nucleoside. The processes according to the invention can be used for the synthesis of a variety of anti-viral agents, including Abacavir, Carbovir, and Entecavir, as well as derivatives thereof.