110895-03-9Relevant academic research and scientific papers
Synthesis of lipophilic aldehydes and study of their inhibition effect on human digestive lipases.
Kotsovolou, Stavroula,Verger, Robert,Kokotos, George
, p. 2625 - 2628 (2002)
[reaction: see text] Novel inhibitors of human digestive lipases, aldehyde dialkyl and alkyl-acyl glycerol analogues, were developed. The inhibitors were prepared starting from 3-(benzyloxy)-1,2-propanediol. The inhibition of human pancreatic and gastric lipases by the aldehyde derivatives was studied using the monolayer technique. (1R)-1-[(Dodecyloxy)methyl]-4-oxobutyl decanoate caused a 50% decrease in HPL and HGL activities at 0.100 and 0.053 molar fractions, respectively.
Synthesis of novel lipophilic tetraamines with cytotoxic activity
Perevoshchikova, Ksenia A.,Nichugovskiy, Artemiy I.,Isagulieva, Alexandra K.,Morozova, Nina G.,Ivanov, Igor V.,Maslov, Mikhail A.,Shtil, Alexander A.
, p. 616 - 618 (2019/11/25)
New lipophilic polyamines in which natural or synthetic tetraamines were linked via the terminal NH2 groups to diglycerides and/or to short-chained aliphatic substituents were synthesized, and their cytotoxic activity was tested. Relationship between the structure of the synthesized compounds and their cytotoxicity and hemolytic effect was evaluated.
