110901-05-8

Upstream product

• 17199-29-0 (S)-Mandelic acid 
• 501-53-1 benzyl chloroformate 
• 103423-01-4 2-(((benzyloxy)carbonyl)oxy)-2-phenylacetic acid 

Downstream Products

• 75475-78-4 O-benzyloxycarbonyl-N-(S)-(1-phenylethyl)-(S)-mandelamide 
• 110811-22-8 O-benzyloxycarbonyl-N-(R)-(1-phenylethyl)-(S)-mandelamide 
• 91578-85-7 (S)-1-phenyl-2-((1S)-1-phenylethylamino)ethan-1-ol 
• 112018-58-3 (S)-2-[(R)-α-methylbenzylamino]-1-phenylethanol 
• 76353-13-4 (S)-N-<(R)-1-phenylethyl>mandelamine 
• 75475-77-3 (S)-2-hydroxy-2-phenyl-N-((S)-1-phenylethyl)acetamide 

Relevant academic research and scientific papers

PROCESS FOR THE SEPARATION OF RACEMIC MIXTURES

The present invention relates to a process for the separation of racemic mixtures comprising development of a denser molecular imprint on silica with a desired enantiomer by sol-gel-protocol comprising hydrolytic control polymerization of a silica source as the monomer and amino alkylsilane as a functional monomer in the presence of the desired enantiomer, capping of surface OH groups and desorption of ancapsulated enantiomer from the silica.

The Preparation and Absolute Configuration of the Optically Active Forms of the Diastereoisomers of 2-(1-Phenylethyl)amino-1-phenylethanol and Their Use as Chiral Auxiliaries in the Asymmetric Reduction of Acetophenone with Modified Lithium Aluminium Hydrides

(1S,2S)-(-)-2-(1-Phenylethyl)amino-1-phenylethanol (4b) (α-form) and the (1S,2R)-(+)-diastereoisomer (4f) (β-form) were prepared by lithium aluminium hydride reduction of the optically active amides derived from the appropriate mandelic acids and 1-phenylethylamines.The preparative methods give the absolute stereochemistry.The aminoethanols (4) were used along with the lower alcohols to prepare chirally modified lithium aluminium hydrides which were in turn used to reduce acetophenone.The optical yields varied, giving at best, under low temperature conditions and use of a 25 percent optical yield.