110901-89-8

Upstream product

• 110901-80-9 (1S,2R)-N-<(R)-2-hydroxy-1-phenylethyl>-2-(3-methoxyphenyl)cyclopropanecarboxamide 
• 6099-04-3 trans-3-methoxycinnamic acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 96728-45-9 (1S,2S)-2-(3-Methoxy-phenyl)-cyclopropanecarbonyl chloride 
• 96728-38-0 trans-[2-(3-methoxyphenyl)cyclopropane]carboxylic acid 
• 38693-90-2 trans-3-(3-methoxyphenyl)acrylic acid methyl ester 

Downstream Products

• 110901-93-4 [(1S,2R)-2-(3-Methoxy-phenyl)-cyclopropyl]-dipropyl-amine 
• 110901-91-2 (1S,2R)-2-(3-Methoxy-phenyl)-cyclopropylamine 

Relevant academic research and scientific papers

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors

A series of trans-2-aryl-cyclopropylamine derived compounds were synthesized and evaluated their biological activities against DPP-IV. The structure-activity relationships (SAR) led to the discovery of novel series of DPP-IV inhibitors, having IC50 values of 100 nM with excellent selectivity over the closely related enzymes, DPP8, DPP-II and FAP. The studies identified a potent and selective DPP-IV inhibitor 24b, which exhibited the ability to both significantly inhibit plasma DPP-IV activity in rats and improve glucose tolerance in lean mice and diet induced obese mice.

N,N-dialkylated monophenolic trans-2-phenylcyclopropylamines: Novel central 5-hydroxytryptamine receptor agonists

N,N-Dialkylated monophenolic derivatives of trans-2-phenylcyclopropylamine were synthesized and tested for central 5-hydroxytryptamine (5-HT) and dopamine (DA) receptor stimulating activity by use of a biochemical test method in rats. A hydroxy substituent in the 2- or 3-position of the phenyl ring was required for 5-HT-receptor stimulation. N,N-Diethyl or N,N-di-n-propyl substitution gave the most potent 5-HT-receptor agonists. The 4-hydroxy and 3,4-dihydroxy derivatives of trans-2-phenyl-N,N-di-n-propylcyclopropylamine were inactive at central DA and 5-HT receptors. In contrast, the corresponding 3-hydroxy derivative 18 and some of its derivatives weakly affected both DA and NE synthesis. Two of the most potent 5-HT-receptor agonists, trans-2-(2-hydroxyphenyl)-N,N-di-n-propylcyclopropylamine (8) and the 3-hydroxy isomer 18 were resolved into the enantiomers. The 1R,2S enantiomers of 8 and 18 displayed 5-HT activity, while the 1S,2R enantiomers were inactive. Compound (1R,2S)-18, but not (1R,2S)-8, weakly affected rat brain DA and NE synthesis.