110911-02-9Relevant academic research and scientific papers
Molecular Mechanics Calculations and the Stereochemical Course of Intramolecular Dipolar Cycloadditions of Nitrile Oxides
Hassner, Alfred,Murthy, K. S. Keshava,Padwa, Albert,Bullock, William H.,Stull, Paul D.
, p. 5063 - 5069 (2007/10/02)
The intramolecular nitrile oxide cycloaddition of a series of 4-vinyl N-substituted β-lactams has been investigated.The synthesis of the olefinic nitrile oxides involves treating a 4-vinylazetidinone with a dibromoalkane.The resulting bromo lactam was con
α-BROMINATION OF ALDOXIMES. A ROUTE TO FUSED AZETIDINES.
Hassner, Alfred,Murthy, Keshava
, p. 683 - 684 (2007/10/02)
Unlike aldehydes and aldoximes, O-silylated aldoximes 2 are smoothly α-brominated with NBS to produce 3, useful intermediates in the conversion to vinylnitroso species or in α-substitution reactions.For instance,3 + 9 * 10 provided precursors for nitrile
STEREOSELECTIVITY DURING INTRAMOLECULAR NITRILE OXIDE OLEFIN CYCLOADDITIONS. SYNTHESIS OF FUSED AZETIDINES.
Hassner, Alfred,Murthy, K. S. Keshava
, p. 4097 - 4100 (2007/10/02)
Vinyl azetidines 7 can be converted to nitro olefins 8,9 or to unsaturated aldoximes 21-23, which are useful precursors for intramolecular nitrile oxide - olefin cycloadditions (INOC).Such INOC reactions proceed with a fair degree of stereoselectivity pro
