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110912-15-7

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110912-15-7 Usage

General Description

3-Chloro-1H-indole-2-carbaldehyde, also known as 3-chloroindole-2-carbaldehyde, is a chemical compound with the molecular formula C9H6ClNO. It is a pale yellow to light brown solid that is commonly used in the synthesis of pharmaceuticals, agricultural chemicals, and other organic compounds. With a melting point of 37-40°C, this compound is a highly reactive aldehyde that can undergo numerous chemical reactions, including condensations and reductions. It is also a key building block in the synthesis of indole-based heterocyclic compounds, which are important in the development of new drugs and functional materials. Overall, the 3-chloro-1H-indole-2-carbaldehyde plays an essential role in organic synthesis and has numerous applications in the fields of pharmaceuticals and chemical research.

Check Digit Verification of cas no

The CAS Registry Mumber 110912-15-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,9,1 and 2 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 110912-15:
(8*1)+(7*1)+(6*0)+(5*9)+(4*1)+(3*2)+(2*1)+(1*5)=77
77 % 10 = 7
So 110912-15-7 is a valid CAS Registry Number.
InChI:InChI=1/C9H6ClNO/c10-9-6-3-1-2-4-7(6)11-8(9)5-12/h1-5,11H

110912-15-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-CHLORO-1H-INDOLE-2-CARBALDEHYDE

1.2 Other means of identification

Product number -
Other names 2-formyl-3-chloroindole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:110912-15-7 SDS

110912-15-7Downstream Products

110912-15-7Relevant articles and documents

Efficient synthesis of some new antiproliferative N-fused indoles and isoquinolines via 1,3-dipolar cycloaddition reaction in an ionic liquid

Sutariya, Tushar R.,Labana, Balvantsingh M.,Parmar, Narsidas J.,Kant, Rajni,Gupta, Vivek K.,Plata, Gabriela B.,Padrón, José M.

, p. 2657 - 2668 (2015)

Syntheses of some new pyrrolo-fused pyrrolo[1,2-a] indole derivatives have been achieved by combining N-allyl-indole-2-carbaldehyde with a variety of N-alkyl-glycine esters as well as tetrahydroisoquinolines in an ionic liquid, triethylammonium acetate (TEAA), a recyclable reaction medium, via intramolecular [3+2] cycloaddition reaction. This new method is highly efficient, and the ionic liquid employed is recyclable. The stereochemistry of all the compounds was confirmed by 2D NMR NOESY and in some cases single crystal X-ray diffraction data. The in vitro screening of all new candidates against various bacterial strains and representative human solid tumor cell lines, A549 (lung), HeLa (cervix), SW1573 (lung), T-47D (breast) and WiDr (colon), revealed that many of them have good antibacterial, antifungal and antitubercular and antiproliferative activities.

Synthesis of some heterocyclic compounds derived from indole as antimicrobial agents

Sayed, Mostafa,Kamal El-Dean, Adel M.,Ahmed, Mostafa,Hassanien, Reda

, p. 413 - 421 (2018)

Recently, indoles are considered interesting heterocyclic compounds due to their wide range of biological activities such as antimicrobial activity. Herein, some new indole derivatives containing heterocyclic moieties were synthesized using 3-chloro-1H-Indole-2-carbaldehyde (1) as a starting material, then allowed to react with compounds containing active methylene under Knoevenagel condensation and afforded the corresponding compounds (2, 3, 9). Also, the compound (1) when allowed to react with hydrazine derivatives gave the corresponding thiosemiccarbazone, semicarbazone, and hydrazone derivatives (4, 5, 6). Reaction of thiosemicarbazone derivatives with α-halognated carbonyl compounds gave the thiazolyl indole derivatives (10, 12a–b). Cyclic chalcones (11a–c) were obtained when compound (10) reacted with different aromatic aldehydes. The structures of all new synthesized compounds were confirmed on the basis of spectral analysis, IR, 1H NMR, 13C NMR, and MS spectroscopy. All synthesized compounds were evaluated for their antimicrobial activity. Compounds (2, 5, 7, 8, 11a, 12a) showed high antibacterial activity and compounds (3, 6, 9, 10, 11a, 12a) showed high antifungal activity.

Efficient preparation method of 3-substitued-benzo five-membered heterocycle-2-carbonyl compound

-

Paragraph 0059-0061, (2017/08/30)

The invention discloses an efficient compounding method of a 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. According to the method, a 3-substitued-benzo five-membered heterocycle-2-alcohol compound is subjected to a halogenated oxidation reaction by a halogenating reagent to generate the corresponding 3-substitued-benzo five-membered heterocycle-2-carbonyl compound. The efficient compounding method has the advantages that raw materials are easy to get, reaction conditions are mild, and reaction selectively and yield are high.

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