110918-98-4

Upstream product

• 110918-96-2 2-(1,3-dithian-2-yliden)propanal 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 110919-02-3 (8R,9R,10S,11R)-10-Benzyloxycarbonylamino-8,11-dimethyl-7-oxa-1,5-dithia-spiro[5.5]undecane-9-carboxylic acid methyl ester 
• 111003-59-9 (8R,9S,10S,11R)-10-Benzyloxycarbonylamino-8,11-dimethyl-7-oxa-1,5-dithia-spiro[5.5]undecane-9-carboxylic acid methyl ester 
• 111003-57-7 (8R,9R,10R,11R)-10-Benzyloxycarbonylamino-8,11-dimethyl-7-oxa-1,5-dithia-spiro[5.5]undecane-9-carboxylic acid methyl ester 
• 110919-04-5 (3R,4R,5S,6R)-4-benzyloxycarbonylamino-3,4,5,6-tetrahydro-5-methoxycarbonyl-3,6-dimethyl-2H-pyran-2-one 
• 110918-99-5 (2R,3S)-3-Benzyloxycarbonylamino-4-[1,3]dithian-2-ylidene-2-((R)-1-hydroxy-ethyl)-pentanoic acid methyl ester 
• 111003-54-4 methyl 3-(R,S)-benzyloxycarbonylamino-4-(1,3-dithian-2-yliden)-2-(R)-(1-(R)-hydroxyethyl)-pentanoate 

Relevant academic research and scientific papers

Optically active beta-amino acid derivatives and their salts, and processes for producing the same

Optically active B-amino acid derivatives and having the following formula: wherein COOR1 is an esterified or unesterified carboxyl group; R2 is hydrogen or a C1-10acyl or esterified carboxyl group and their salts, and novel compounds which permit important intermediate for the synthesis of 1B-methylcarbapenem derivatives to be produced in an efficient way.

A STEREOSELECTIVE APPROACH TO 1β-METHYLCARBAPENEM ANTIBIOTIC STARTING FROM (R)-(-)-3-HYDROXYBUTYRIC ACID ESTER

The chiral key intermediate of 1β-methylcarbapenem antibiotic is synthesized via (2R,3R,4S,5R)-3-amino-2,5-dimethyl-5-pentanolide-4-carboxylic acid, which is prepared in a stereoselective manner from (R)-(-)-hydroxy-butyrate.