110925-97-8

Upstream product

• 33431-40-2 6-<(2E,6E)farnesyl>-5,7-dihydroxy-4-methylphthalide 
• 64-17-5 ethanol 
• 1028183-07-4 3,3-dimethoxypentanoyl chloride 
• 78133-88-7 1,3-bis(trimethylsiloxy)-1-methoxypenta-1,3-diene 

Relevant academic research and scientific papers

Regioselective synthesis of functionalized resorcins by cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3,3-dimethoxypentanoyl chloride

Functionalized resorcins are regioselectively prepared by cyclization of 1,3-bis(trimethylsilyloxy)-1,3-butadienes with 3,3-dimethoxypentanoyl chloride. The regioselectivity is controlled by the type of Lewis acid employed. Georg Thieme Verlag Stuttgart.

Metabolites of Aspergillus ustus. Part 4. Stable-isotope Labelling Studies on the Biosynthesis of the Austalides

Incorporation of -, - and -acetate, and (3RS)-mevalonolactone into austalide D (2), a metabolite of Aspergillus ustus, shows that the austalides are derived from 6--5,7-dihydroxy-4-methylphthalide.The proposed mechanism for the subsequent cyclisation and oxidative modifications of the farnesyl moiety, consistent with the relative stereochemistry of the austalides and the structures of the cometabolites, austalides J (4), K (5), and L (6), is supported by the incorporation of austalide K into austalide D.The addition of ethanol to growing cultures of A. ustus severely inhibits normal metabolite production and induces the formation of a new metabolite, ethyl 6-ethyl-2,4-dihydroxy-3-methylbenzoate (11).The biosynthetic origin of this metabolite was studied using - and acetate and (2S)-methionine as precursors.