1109268-82-7Relevant academic research and scientific papers
Improved robust method for preparing optically active 3-alkyl-3-phenyl-1,4- dioxane-2,5-diones; A promising new chiral template
Nagase, Ryohei,Iida, Yuuki,Sugi, Mikiko,Misaki, Tomonori,Tanabe, Yoo
experimental part, p. 3670 - 3674 (2009/07/25)
A robust method for preparing (3S)-3-alkyl-3-phenyl-1,4-dioxane-2,5-diones was developed using an improved cyclocondensation reaction between (S)-α-alkylmandelic acids and 2-bromocarbonyl halides. Subtle differences in the reaction conditions, including separate additions of triethylamine, significantly increased the yield compared with Schollkopf s original method. Georg Thieme Verlag Stuttgart · New York.
