110927-00-9Relevant articles and documents
N,N-disubstituted aminomethyl benzofuran derivatives: Synthesis and preliminary binding evaluation
Boye, Sophie,Pfeiffer, Bruno,Renard, Pierre,Rettori, Marie-Claire,Guillaumet, Gerald,Viaud, Marie-Claude
, p. 335 - 341 (2007/10/03)
A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT(1A), 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT(1A) sites with nanomolar affinity (IC50=1.5nM) and high selectivity over 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Copyright (C) 1999 Elsevier Science Ltd.
SUBSTITUTED 3-AMINO CHROMANS
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, (2008/06/13)
The present invention is directed to novel chromane derivatives substituted in the 3-position by a substituted amino moiety and substituted on the aromatic ring with one or two substituents. The novel chromane derivatives have useful CNS properties. STR1
Synthesis of 3-dialkylaminochromans via thallium(III)-induced cyclization of allyl aryl ethers.
Andersson,Wikstroem,Hallberg
, p. 1024 - 1028 (2007/10/02)
The sulfur-containing 3-alkylaminochromans, 5-methoxy-3-[N-(2- methylthioethyl)-propylamino]chroman (15), 5-hydroxy-3-[N-(2-methylthioethyl)propylamino]chroman (5) and 5-methoxy-8-methylthio-3-(dipropylamino)chroman (6), have been prepared from 8-bromo-5-