1109284-47-0

Basic information

• Product Name: tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate
• Synonyms: tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate
• CAS NO: 1109284-47-0
• Molecular Weight: 250.289
• Mol File: 1109284-47-0.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate(1109284-47-0)
• EPA Substance Registry System: tert-butyl [(1R,6S)-6-amino-2,2-difluorocyclohexyl]carbamate(1109284-47-0)

Safety Data

• Hazardous Substances Data: 1109284-47-0(Hazardous Substances Data)

Upstream product

• 1109284-44-7 tert-butyl (1R,6S)-6-azido-2,2-difluorocyclohexylcarbamate 

Downstream Products

• 1314893-34-9 N-[(1R,6S)-6-amino-2,2-difluorocyclohexyl]-5-ethyl-4-(6-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide 
• 1314893-30-5 N-[(1R,6S)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-ethylthiophene-2-carboxamide 
• 1235545-48-8 (1R,6S)-6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-2,2-difluorocyclohexanaminium chloride 
• 1235545-49-9 tert-butyl 9H-fluoren-9-ylmethyl [(1S,2R)-3,3-difluorocyclohexane-1,2-diyl]biscarbamate 

Relevant articles and documents

PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS

The invention encompasses pyrazolo[1,5-a]pyridine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS

The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

Compounds of the following formula (I) are inhibitors of microtubule affinity regulating kinase, and hence find use in the treatment of neurodegenerative diseases associated with hyperphosphorylation of tau.