110932-28-0

Basic information

• Product Name: [(4-tert-butylphenyl)methyl](propan-2-yl)amine
• Synonyms: [(4-tert-butylphenyl)methyl](propan-2-yl)amine
• CAS NO: 110932-28-0
• Molecular Formula: C₁₄H₂₃N
• Molecular Weight: 205.34
• Mol File: 110932-28-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: [(4-tert-butylphenyl)methyl](propan-2-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-tert-butylphenyl)methyl](propan-2-yl)amine(110932-28-0)
• EPA Substance Registry System: [(4-tert-butylphenyl)methyl](propan-2-yl)amine(110932-28-0)

Safety Data

• Hazardous Substances Data: 110932-28-0(Hazardous Substances Data)

Upstream product

• 19692-45-6 4-tert-butylbenzyl chloride 
• 75-31-0 isopropylamine 

Relevant articles and documents

Efficient Synthesis of Trifluoromethyl Amines through a Formal Umpolung Strategy from the Bench-Stable Precursor (Me4N)SCF3

Reported herein is the one-pot synthesis of trifluoromethylated amines at room temperature using the bench-stable (Me4N)SCF3reagent and AgF. The method is rapid, operationally simple and highly selective. It proceeds via a formal umpolung reaction of the SCF3with the amine, giving quantitative formation of thiocarbamoyl fluoride intermediates within minutes that can readily be transformed to N-CF3. The mildness and high functional group tolerance render the method highly attractive for the late-stage introduction of trifluoromethyl groups on amines, as demonstrated herein for a range of pharmaceutically relevant drug molecules.