110945-00-1 Usage
General Description
Ethanone, 2-chloro-1-[4-(dimethylamino)phenyl]- (9CI) is a chemical compound with the molecular formula C10H11ClNO. It is also known by its 9CI name, 2-chloro-1-(4-dimethylaminophenyl)ethanone. Ethanone, 2-chloro-1-[4-(dimethylamino)phenyl]- (9CI) is a member of the ketone functional group and contains a chloro and dimethylamino substituent. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceuticals. Additionally, it is studied for its potential biological properties and pharmacological activities, particularly in relation to its interactions with biological targets such as enzymes and proteins. As a result, this compound is of interest for researchers in the field of medicinal chemistry and drug development.
Check Digit Verification of cas no
The CAS Registry Mumber 110945-00-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,0,9,4 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 110945-00:
(8*1)+(7*1)+(6*0)+(5*9)+(4*4)+(3*5)+(2*0)+(1*0)=91
91 % 10 = 1
So 110945-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H12ClNO/c1-12(2)9-5-3-8(4-6-9)10(13)7-11/h3-6H,7H2,1-2H3
110945-00-1Relevant articles and documents
Selective Asymmetric Transfer Hydrogenation of α-Substituted Acetophenones with Bifunctional Oxo-Tethered Ruthenium(II) Catalysts
Yuki, Yamato,Touge, Taichiro,Nara, Hideki,Matsumura, Kazuhiko,Fujiwhara, Mitsuhiko,Kayaki, Yoshihito,Ikariya, Takao
supporting information, p. 568 - 574 (2017/12/13)
A practical method for the asymmetric transfer hydrogenation of α-substituted ketones was developed utilizing oxo-tethered N-sulfonyldiamine-ruthenium complexes. Reduction by HCO2H and HCO2K in a mixed solvent of EtOAc/H2O allowed for the selective synthesis of halohydrins from 2-bromoacetophenone (98%) and 2-chloroacetophenone (>99%), leading to suppressed undesired side reactions stemming from formylation under the typical reaction conditions using an azeotropic 5:2 mixture of HCO2H and Et3N. A range of functional groups, such as halogens, methoxy, nitro, dimethylamino, and ester groups, were well tolerated, highlighting the potential of this method. Nearly complete selectivity with a preferable ee was maintained even with a substrate/catalyst (S/C) ratio of 5000. This catalyst system was also effective for the asymmetric reduction of α-sulfonated ketones without eroding the leaving group. (Figure presented.).
