110965-58-7Relevant academic research and scientific papers
hTERT MODULATORS AND METHODS OF USE
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Paragraph 0093; 0094; 0095; 0152, (2018/02/28)
The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which results in reversal of the effect of mutant promoter activation.
Synthesis and antitumor activities of novel benzoylphenylurea derivatives
Okada,Koyanagi,Yamada,Haga
, p. 2308 - 2315 (2007/10/02)
Seventy novel benzoylphenylurea compounds were synthesized and their antitumor activities were examined in vivo against P388 leukemia. N-(2-Nitrobenzoyl)-N'-[4-(2-pyrimidinyloxy)phenyl]ureas showed the highest antitumor activities when dosed intraperitoneally or orally. Their structure-activity relationships were examined with particular focus on the position and the variety of substituent on each aryl ring.
