110971-02-3

Basic information

• Product Name: d6-coenzyme Q₁₀
• Synonyms: d6-coenzyme Q₁₀
• CAS NO: 110971-02-3
• Molecular Weight: 869.314
• Mol File: 110971-02-3.mol

Chemical Properties

• CAS DataBase Reference: d6-coenzyme Q₁₀(CAS DataBase Reference)
• NIST Chemistry Reference: d6-coenzyme Q₁₀(110971-02-3)
• EPA Substance Registry System: d6-coenzyme Q₁₀(110971-02-3)

Safety Data

• Hazardous Substances Data: 110971-02-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
d6-coenzyme Q10 is used as a dietary supplement for enhancing cellular energy production and supporting overall health. It is particularly beneficial for individuals with certain medical conditions that affect energy production in the body.
Used in Healthcare Industry:
d6-coenzyme Q10 is used as a therapeutic agent for improving heart health and managing the symptoms of specific medical conditions. Its antioxidant properties also contribute to the prevention of cell damage caused by free radicals.
Used in Nutraceutical Industry:
d6-coenzyme Q10 is used as an ingredient in health and wellness products, targeting consumers seeking natural ways to support their overall health and well-being.
Used in Cosmetic Industry:
d6-coenzyme Q10 is used as an active ingredient in anti-aging and skin care products, leveraging its antioxidant properties to protect the skin from environmental damage and promote a youthful appearance.
Used in Research and Development:
d6-coenzyme Q10 is utilized in scientific research to explore its potential health benefits and applications in various medical and therapeutic areas, as well as to develop innovative formulations and delivery systems for improved efficacy and bioavailability.

Upstream product

• 811-98-3 d⁽⁴⁾-methanol 
• 28527-67-5 diethoxy-CoQ₁₀ 
• 144296-57-1 C₂₃H₁₄⁽²⁾H₆O₆ 
• 144296-55-9 C₂₃H₂₀O₆ 
• 144296-56-0 C₂₁H₁₆O₆ 
• 131135-41-6 C₉H₄⁽²⁾H₆O₄ 
• 144296-58-2 C₉H₆⁽²⁾H₆O₄ 
• 3066-90-8 2,3-dimethoxy-5-methylbenzene-1,4-diol 
• 605-94-7 2,3-Dimethoxy-5-methyl-1,4-benzoquinone 
• 144296-59-3 C₅₉H₈₆⁽²⁾H₆O₄ 

Relevant articles and documents

Coenzyme Q10 quantification in muscle, fibroblasts and cerebrospinal fluid by liquid chromatography/tandem mass spectrometry using a novel deuterated internal standard

RATIONALE Neurological dysfunction is common in primary coenzyme Q 10 (2,3-dimethoxy, 5-methyl, 6-polyisoprene parabenzoquinone; CoQ10; ubiquinone) deficiencies, the most readily treatable subgroup of mitochondrial disorders. Therapeutic benefit from CoQ10 supplementation has also been noted in other neurodegenerative diseases. CoQ10 can be measured by high-performance liquid chromatography (HPLC) in plasma, muscle or leucocytes; however, there is no reliable method to quantify CoQ10 in cerebrospinal fluid (CSF). Additionally, many methods use CoQ9, an endogenous ubiquinone in humans, as an internal standard. METHODS Deuterated CoQ10 (d6-CoQ10) was synthesised by a novel, simple, method. Total CoQ10 was measured by liquid chromatography/tandem mass spectrometry (LC/MS/MS) using d 6-CoQ10 as internal standard and 5 mM methylamine as an ion-pairing reagent. Chromatography was performed using a Hypsersil GOLD C4 column (150 × 3 mm, 3 μm). RESULTS CoQ10 levels were linear over a concentration range of 0-200 nM (R2 = 0.9995). The lower limit of detection was 2 nM. The inter-assay coefficient of variation (CV) was 3.6% (10 nM) and 4.3% (20 nM), and intra-assay CV 3.4% (10 nM) and 3.6% (20 nM). Reference ranges were established for CoQ10 in CSF (5.7-8.7 nM; n = 17), fibroblasts (57.0-121.6 pmol/mg; n = 50) and muscle (187.3-430.1 pmol/mg; n = 15). CONCLUSIONS Use of d6-CoQ10 internal standard has enabled the development of a sensitive LC/MS/MS method to accurately determine total CoQ10 levels. Clinical applications of CSF CoQ10 determination include identification of patients with cerebral CoQ10 deficiency, and monitoring CSF CoQ10 levels following supplementation. Copyright 2013 John Wiley & Sons, Ltd. Copyright

Synthesis of isotopically labelled ubiquinones

Ubiquinones (1) of various chain lengths have been synthesized. The key step involves the condensation of a long chain polyunsaturated alcohol onto an aromatic intermediate. The synthetic methodology allows for the incorporation of isotopic labels in the methoxy groups attached to the ring portion of the molecule.