110997-87-0

Basic information

• Product Name: BENZENAMINE, 4-[2-(3-METHOXYPHENYL)ETHYL]-
• Synonyms: 4-[2-(3-METHOXYPHENYL)ETHYL]-BENZENAMINE;BENZENAMINE, 4-[2-(3-METHOXYPHENYL)ETHYL]-;4-[2-(3-methoxyphenyl)ethyl]aniline
• CAS NO: 110997-87-0
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.305
• Mol File: 110997-87-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZENAMINE, 4-[2-(3-METHOXYPHENYL)ETHYL]-(CAS DataBase Reference)
• NIST Chemistry Reference: BENZENAMINE, 4-[2-(3-METHOXYPHENYL)ETHYL]-(110997-87-0)
• EPA Substance Registry System: BENZENAMINE, 4-[2-(3-METHOXYPHENYL)ETHYL]-(110997-87-0)

Safety Data

• Hazardous Substances Data: 110997-87-0(Hazardous Substances Data)

Upstream product

• 60822-58-4 1-methoxy-3-[2-(4-nitrophenyl)ethenyl]benzene 

Downstream Products

• 1186335-61-4 N-{4-[2-(3-methoxyphenyl)ethyl]phenyl}phthalimide 
• 1186335-70-5 4,5,6,7-tetrachloro-N-{4-[2-(3-methoxyphenyl)ethyl]phenyl}phthalimide 

Relevant articles and documents

Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide

Swine-origin influenza A virus has caused pandemics throughout the world and influenza A is regarded as a serious global health issue. Hence, novel drugs that will target these viruses are very desirable. Influenza A expresses an RNA polymerase essential for its transcription and replication which comprises PA, PB1, and PB2 subunits. We identified potential novel anti-influenza agents from a screen of 34 synthesized phenethylphenylphthalimide analogs derived from thalidomide (PPT analogs). For this screen we used a PA endonuclease inhibition assay, a PB2 pathogenicity-determinant domain-binding assay, and an anti-influenza A virus assay. Three PPT analogs, PPT-65, PPT-66, and PPT-67, were found to both inhibit PA endonuclease activity and retard the growth of influenza A, suggesting a correlation between their activities. PPT-28 was also found to inhibit the growth of influenza A. These four analogs have a 3,4-dihydroxyphenethyl group in common. We also discuss the possibility that 3,4-dihydroxyphenethyl group flexibility may play an important functional role in PA endonuclease inhibition. Another analog harboring a dimethoxyphenethyl group, PPT-62, showed PB2 pathogenicity-determinant domain-binding activity, but did not inhibit the growth of the virus. Our present results indicate the utility of the PA endonuclease assay in the screening of anti-influenza drugs and are therefore useful for future strategies to develop novel anti-influenza A drugs and for mapping the function of the influenza A RNA polymerase subunits.

(N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade

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Enolamides, pharmaceutical compositions and methods for treating inflammation

The present invention relates to novel enolamide type compounds, pharmaceutical compositions, and methods of use thereof, useful in the treatment of diseases in which products of lipoxygenase enzyme activity or the action of leukotrienes contribute to the