1110-80-1 Usage
Uses
Used in Pharmaceutical Industry:
Pipacycline is used as a semi-synthetic tetracycline antibiotic for treating various bacterial infections. The improved bioavailability due to the piperazine group enhances its effectiveness in combating infections caused by susceptible bacteria.
Used in Combination Therapy:
Pipacycline is used as a component in combination therapy with penicillin V, forming penimepicycline. This combination is utilized for parenteral use, providing a broader spectrum of activity against bacteria and potentially reducing the likelihood of resistance development.
Originator
Sieromicin,Sierochimica,Italy,1962
Manufacturing Process
1.55 g p-formaldehyde were added to a solution of 7 g N-(β-hydroxyethyl)- diethylene diamine in 150 cc isopropanol and the whole was heated to 60°C for 30 minutes, to obtain complete dissolution; after cooling the solution to 40°C, 22.2 g of anhydrous tetracycline base were added as a fine powder and the reaction was allowed to proceed for 3 hours with agitation and while passing through a current of dry nitrogen; the solution was then filtered on a Buchner funnel and the filter cake was washed twice with 20 cc isopropanol; the crystalline cake was resuspended in 100 cc anhydrous ether, again filtered and washed 3 times with 50 cc anhydrous ether; finally, it was dried in vacuo and 28.6 g of product were obtained, namely a yield of 98%. The characteristics of this product are as follows. It is a pale yellow, nonodorous, slightly bitter, crystalline powder, very soluble in water (>1.5 g/cc), soluble in methanol and formamide, slightly soluble in ethanol and isopropanol, insoluble in ether, benzene and chloroform; MP 162° to 163°C with decomposition (uncorrected).
Therapeutic Function
Antimicrobial
Check Digit Verification of cas no
The CAS Registry Mumber 1110-80-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,1 and 0 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1110-80:
(6*1)+(5*1)+(4*1)+(3*0)+(2*8)+(1*0)=31
31 % 10 = 1
So 1110-80-1 is a valid CAS Registry Number.
InChI:InChI=1/C29H38N4O9/c1-28(41)15-5-4-6-18(35)19(15)23(36)20-16(28)13-17-22(31(2)3)24(37)21(26(39)29(17,42)25(20)38)27(40)30-14-33-9-7-32(8-10-33)11-12-34/h4-6,16-17,22,30,34-36,40-42H,7-14H2,1-3H3/b27-21-
