111016-49-0

Upstream product

• 105962-51-4 cis-4-p-chlorophenyl-3-benzamido-3-carbomethoxy-Δ¹-pyrazoline 
• 1415402-14-0 4-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole 
• 105962-47-8 cis-4-p-chlorophenyl-3-acetamido-3-carbomethoxy-Δ¹-pyrazoline 
• 102245-02-3 methyl (Z)-2-acetylamino-3-(4-chlorophenyl)-2-propenoate 
• 111016-44-5 4-(4-chloro-phenyl)-1⁽²⁾H-pyrazole-3-carboxylic acid methyl ester 
• 82301-66-4 (Z)-N-benzoylamino-3-(4-chlorophenyl) acrylic acid methyl ester 

Downstream Products

• 111016-47-8 4-(4-chlorophenyl)-1H-pyrazole 

Relevant academic research and scientific papers

Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of Suzuki-Miyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

NEW EFFICIENT SYNTHESIS OF 3(5)-CARBOMETHOXY-4-ARYLPYRAZOLES FROM 3-ARYL-2,3-DEHYDROAMINO ACID DERIVATIVES

3(5)-Carbomethoxy-4-arylpyrazoles can be easily obtained by aromatization with boron trifluoride etherate of 4-aryl-3-acetamido(or benzamido)-3-carbomethoxy-Δ1-pyrazolines synthesized by 1,3-dipolar cycloaddition of diazomethane with 3-aryl-2,3